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Cytosponge-trefoil factor 3 versus usual care to identify Barrett’s oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial. Lancet 2020; 396: 333-344.

Published: 16th September 2020

Authors: Fitzgerald RC, di Pietro M, O’Donovan M, Maroni R, Muldrew B, Debiram-Beeecham I et al.


People over 50 with symptoms of gastro-oesophageal reflux for at least six months were included. Some 39 per cent of those offered the sponge procedure accepted it. In the next 12 months, Barrett’s was diagnosed in 140/6834 of those offered the sponge, compared to 13/6388 in the usual care group.

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