This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Secondary chemoprevention of Barrett’s esophagus with celecoxib: results of a randomised trial. J Natl Cancer Inst 2007; 99: 545-557.

Published: 1st January 2007

Authors: Heath EI, Canto MI, Piantadosi S, Montgomery E, Weinstein WM, Herman JG et al.

Conclusion

Celecoxib 200mg twice daily for one year had no effect on the progression of the dysplasia in 100 patients with Barrett’s oesophagus.

Pubmed Link

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IMPPACT (Intravenous Monotherapy for Postoperative Perforated Appendicitis in Children Trial). Randomized clinical trial of monotherapy versus multi-drug antibiotic therapy. Ann Surg 2021; 274: 406-410.

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