This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Dexamethasone and surgical-site infection. N Engl J Med 2021; 384: 1731-1741.

Published: 1st November 2021

Authors: Corcoran TB, Myles PS, Forbes AB, Cheng AC, Bach LA, O’Loughlin E et al.

Conclusion

A single perioperative dose of 8mg dexamethasone reduced the rate of surgical site infection from 9.1 to 8.1 per cent (P<0.001) in this study that included 8725 procedures. It also reduced postoperative nausea and vomiting: risk ratio 0.78, 95 per cent confidence interval 0.75 to 0.82.

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