This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med 2013; 369: 1406-1415.

Published: 14th April 2014

Authors: The Hokusai-VTE Investigators

Conclusion

Over 8000 patients with acute venous thromboembolism were included. Recurrent symptomatic thromboembolism occurred in 3.2 per cent with edoxaban versus 3.5 per cent on warfarin (P<0.001 for non-inferiority). Rates of major or clinically relevant bleeding were higher with warfarin: 10.3 versus 8.5 per cent, P=0.004.

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