This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs. observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial. JAMA 2012; 308: 147–156.
Published: 9th May 2013
Authors: Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC et al. et al.
Conclusion
Some 428 patients were randomized to one of two chemotherapy regimens or a control group. Although the subsequent mortality rate was similar in each group, multivariable analysis adjusting for prognostic factors suggested a significant survival benefit from adjuvant chemotherapy: hazard ratio 0.75, 95 per cent confidence interval 0.57 to 0.98, P=0.03.
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