This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Effect of tailored dose-dense chemotherapy vs standard 3-weekly adjuvant chemotherapy on recurrence-free survival among women with high-risk early breast cancer. A randomized clinical trial. JAMA 2016; 316: 1888-1896.
Published: 20th December 2016
Authors: Foukakis T, von Minckwitz G, Bengtsson N-O, Brandberg Y, Wallberg B, for the Swedish Breast Cancer Group (SweBCG), the German Breast Group (GBG), and the Austrian Breast & Colorectal Cancer Study Group (ABCSG) et al.
Conclusion
The use of dose-dense chemotherapy did not improve five year breast cancer-free survival (88.7 versus 85 per cent in controls), or overall survival (92.1 versus 90.2 per cent) in this study that included 2017 women.
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