This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Effectiveness of flexible sigmoidoscopy screening in men and women and different age groups: pooled analysis of randomised trials. BMJ 2017; 356: i6673.

Published: 1st March 2017

Authors: Holme Ø , Schoen RE, Senore C, Segnan N, Hoff G, Løberg M et al.

Conclusion

Data from three large RCTs were pooled. In men, screening reduced the incidence of colorectal cancer after 10.5 to 11.9 years of follow-up: relative risk 0.79, 95 per cent confidence intervals 0.70 to 0.83. Screening also reduced cancers in women under 60 years (0.71, 0.59 to 0.84), but not in those older (0.9, 0.8 to 1.02), due to tumours in the proximal colon.

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