This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Long term effects of once-only flexible sigmoidoscopy screening after 17 years of follow-up: the UK Flexible Sigmoidoscopy Screening randomised controlled trial. Lancet 2017; 389: 1299–1311.

Published: 26th April 2017

Authors: Atkin W , Wooldrage K, Parkin DM, Kralj-Hans I, MacRae E, Shah U et al.

Conclusion

A total of 170,034 people were included; 40,621 had sigmoidoscopy. Invitation to screening reduced the risk of developing colorectal cancer by 26 percent (hazard ratio 0.74, 95 per cent confidence interval 0.7 to 0.8, P<0.0001), and death from colorectal cancer by 30 per cent (0.7, 0.62 to 0.79, P<0.0001).

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