This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Once-only sigmoidoscopy in colorectal cancer screening: follow-up findings of the Italian randomized controlled trial – SCORE. J Natl Cancer Inst 2011; 103: 1310–1322.
Published: 21st February 2012
Authors: Segnan N, Armaroli P, Bonelli L, Risio M, Sciallero S, Zappa M et al. et al.
Conclusion
Almost 35,000 people were included in this study and followed for eleven years. Screening significantly reduced the rate of colorectal cancer by 18 per cent (95 per cent confidence interval 4 to 31 per cent), but the mortality reduction of 22 per cent was not significant (relative risk 0.78, 95 per cent confidence interval 0.56 to 1.08).
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