This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Efficacy and safety of nonantibiotic outpatient treatment in mild acute diverticulitis (DINAMO-study). A multicentre, randomised, open-label, noninferiority trial. Results from a multicenter randomized controlled trial (HOPE ECD-DBD). Ann Surg 2021; 274: e435-e442.
Published: 9th December 2021
Authors: Mora-López L, Ruiz-Edo N, Estrada-Ferrer O, Piñana-Campón ML, Labró-Ciurans M, Escuder-Perez J et al.
Some 480 patients with uncomplicated diverticulitis treated in one of 15 hospital emergency departments as an outpatient were included. Hospital admission was required in 3.3 per cent of patients who did not receive antibiotics and 5.8 per cent of those who did.Pubmed Link
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Comparing laparoscopic elective sigmoid resection with conservative treatment in improving quality of life of patients with diverticulitis. The Laparoscopic Elective Sigmoid Resection Following Diverticulitis (LASER) randomized clinical trial. JAMA Surg 2021; 156: 129-136.
Authors: Santos A, Mentula P, Pinta T, Ismael S, Rautio T, Juusela R et al.
Laparoscopic lavage vs primary resection for acute perforated diverticulitis. Long-term outcomes from the Scandinavian Diverticulitis (SCANDIV) randomized clinical trial. JAMA Surg 2021; 156: 121-127.
Authors: Azhar N, Johanssen A, Sundstrom T, Folkesson J, Wallon C, Korner H et al.
Prospectively randomized controlled trial on damage control surgery for perforated diverticulitis with generalized peritonitis. World J Surg 2020; 44: 4098-4105.
Authors: Kafka-Ritsch R, Zitt M, Perathoner A, Gasser E, Kaufman C, Czipin S et al.
Authors: Beyer-Berjot L, Maggiori L, Loiseau D, Korwin J-D, Bongiovanni J-P, Lesprit P et al.
Hartmann’s procedure versus sigmoidectomy with primary anastomosis for sigmoid diverticulitis with purulent or faecal peritonitis (LADIES): a multicenter, parallel-group, open label superiority trial. Lancet Gastroenterol Hepatol 2019; 4: 599-610
Authors: Lambrichts DPV, Vennix S , Musters GD , Mulder IM , Swank HA , Hoofwijk AGM et al.
Long-term outcome of surgery versus conservative management for recurrent and ongoing complaints after an episode of diverticulitis. 5-year follow-up results of a multicenter randomized controlled trial (DIRECT-Trial). Ann Surg 2019; 269: 612-620.
Authors: Bolkenstein HE, Consten ECJ, van der Palen J, van de Wall BJ, Broeders IA, Bemelman WA et al.
Operative strategies for perforated diverticulitis. A systematic review and meta-analysis. Dis Colon Rectum 2018; 61: 1442-1453.
Authors: Acuna SA, Wood T, Chesney TR, Dossa F, Wexner SDS, Quereshy F et al.
The role of antibiotics in acute uncomplicated diverticulitis: A systematic review and meta-analysis. Am J Surg 2018; 216: 604–609.
Authors: Mocanu V, Dang JT, Switzer N, Tavakoli I, Tian C, de Gara C et al.
Hartmann’s procedure or primary anastomosis for generalized peritonitis due to perforated diverticulitis: a prospective multicenter randomized trial (DIVERTI). J Am Coll Surg 2017; 225: 798-805.
Authors: Bridoux V, Regimbeau JM, Ouassi M, Mathonnet M, Mauvais F, Houivet E et al.
Laparoscopic lavage versus primary resection for acute perforated diverticulitis: review and meta-analysis. Ann Surg 2018; 267: 252-258.
Authors: Penna M, Markar SR, Mackenzie H, Hompes R, Cunningham C
Laparoscopic lavage in the management of Hinchey Grade III diverticulitis: a Systematic review. Ann Surg 2017; 265: 670-676.
Authors: Marshall J, Buchwald P, Gandhi J, Schultz JK, Hider PN, Frizelle F et al.
Surgery versus conservative treatment for recurrent and ongoing left-sided diverticulitis (DIRECT Trial): an open-label, multicentre, randomised controlled trial. Lancet Gastroenterol Hepatol 2017; 2: 13-22.
Authors: Van de Wall BJM, Stam MAW, Draaisma WA, Stellato R, Bemelman WA, Boermeester MA et al.