This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Efficacy and safety of the new oral anticoagulants dabigatran, rivaroxaban, apixaban, and edoxaban in the treatment and secondary prevention of venous thromboembolism: a systematic review and meta-analysis of phase III trials. Eur J Vasc Endovasc Surg. 2014; 48: 565-575.

Published: 20th May 2015

Authors: Kakkos SK, Kirkilesis GI, Tsolakis IA

Conclusion

This was a meta-analysis of ten randomized trials that included 38,000 patients. In the six treatment trials, the new agents were as effective as warfarin, but with fewer bleeding complications. In the three secondary prevention trials, the new agents were effective at reducing recurrent venous thromboembolism, and all-cause mortality.

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