This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischaemia: the Carotid Occlusion Surgery Study randomized trial. JAMA 2011; 306: 1983-1992.
Published: 5th March 2012
Authors: Powers WJ, Clarke WR, Grubb RL Jr, Videen TO, Adams HP Jr, Derdeyn CP et al.
Conclusion
Patients with haemodynamic cerebral ischaemia (measured on PET scanning) and a recently symptomatic acute carotid artery occlusion were included. The trial was terminated early for futility after 195 patients had been randomized: two year stroke and death rates were 21 per cent after surgery and 23 per cent in controls.
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