The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 2006; 355: 549¿559.

Published: 1st January 2006

Authors: The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) investigators.

Conclusion

A total of 4731 patients were followed for a median of 4.9 years. Overall mortality rates were similar. Atorvastatin reduced the rate of fatal and non fatal stroke from 13.1 to 11.2 per cent (hazard ratio 0.84, 95 per cent confidence interval 0.71 to 0.99, P=0.03).

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