This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Oral and parenteral versus parenteral antibiotic prophylaxis in elective laparoscopic colorectal surgery (JMTO PREV 07–01): a phase 3, multicenter, open-label, randomized trial. Ann Surg 2016; 263: 1085-1091.

Published: 25th August 2016

Authors: Hata H, Yamaguchi T, Hasegawa S, Nomura A, Hida K, Nishitai R et al.

Conclusion

The addition of oral antibiotics to standard parenteral antibiotic prophylaxis reduced the rate of surgical site infection from 12.8 to 7.3 per cent in this study that included 579 patients: odds ratio 0.54, 95 per cent confidence interval 0.305 to 0.94, P=0.028.

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