This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Preoperative enoxaparin versus postoperative semuloparin thromboprophylaxis in major abdominal surgery: a randomized controlled trial. Ann Surg 2014; 259: 1073-1079.

Published: 11th September 2014

Authors: Kakkar AK, Agnelli G, Fisher W, George D, Lassen MR, Mismetti P et al. et al.

Conclusion

Semuloparin is a new ultra low molecular weight heparin. In this study that included 4413 patients, it was non-inferior to enoxaparin (postoperative venous thromboembolism or death 6.3 versus 5.5 per cent, respectively), without increased risk of serious bleeding (2.9 versus 4.5 per cent).

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