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Prophylactic antibiotics reduce pancreatic necrosis in acute necrotizing pancreatitis: a meta-analysis of randomized trials. Digest Surg 2010; 27: 442–449.

Published: 4th May 2011

Authors: Yao L, Huang X, Shi R, Zhang G.


The nine trials analysed included 564 patients. Antibiotics did not affect the mortality rate (P=0.1), or the need for surgical intervention (P=0.17), but they did reduce the rate of infected pancreatic necrosis: relative risk 0.73, 95 per cent confidence interval 0.54 to 0.98, P=0.04.

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