This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Prospective randomized double-blinded trial comparing 2 anti-MRSA agents with supplemental coverage of cefazolin before lower extremity revascularization. Ann Surg 2015; 262: 495–501.
Published: 15th December 2015
Authors: Stone P, AbuRahma, AF, Campbell JR, Hass S, Mousa AY et al.
Conclusion
The study included 178 patients undergoing bypass surgery. The addition of either vancomycin or daptomycin to standard cephalosporin prophylaxis had a similar effect: surgical site infection rates 8.2 and 11.8 respectively. Vancomycin appeared to reduce the rate of Gram positive bacterial infections.
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