The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Randomized, placebo-controlled, double-blind study of the efficacy of lanreotide 30 mg PR in the treatment of pancreatic and enterocutaneous fistulae. Ann Surg 2009; 250: 872-877.

Published: 1st January 2009

Authors: Gayral F, Campion J-P, Regimbeau J-M, Blumberg J, Masionobe P, Topart P et al. et al.

Conclusion

This study included 107 patients; responders were classified by a 50 per cent reduction in fistula output within 72h of treatment. Responders then continued with treatment by intramuscular injection. Response rates were 65 per cent with lanreotide vs. 38 per cent with placebo (P=0.006), but overall fistula closure rates were similar in the two groups.

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