The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Relationship between intraoperative fluid administration and perioperative outcome after pancreaticoduodenectomy: results of a prospective randomized trial of acute normovolemic hemodilution compared with standard intraoperative management. Ann Surg 2010; 252: 952–958.

Published: 4th April 2011

Authors: Fischer M, Matsuo K, Gonen M, Grant F, DeMatteo RP, D’Angelica MI et al. et al.

Conclusion

Haemodilution resulted in a greater need for intra-operative fluid resuscitation (6250 vs. 3900ml, P<0.001) without reducing the requirement for blood transfusion in this study of 130 procedures. There was a trend towards a higher rate of pancreatic duct anastomotic complications in the treatment group: 32 vs. 23.1 per cent, P=0.17.

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