This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Six months versus 12 months of adjuvant trastuzumab in early breast cancer (PHARE): final analysis of a multicentre, open-label, phase 3 randomised trial. Lancet 2019; 393: 2591-2598.
Published: 2nd September 2019
Authors: Pivot X, Romieu G, Debled M, Pierga J-Y, Kerbrat P, Bachelot T et al.
Conclusion
This study included 3384 women followed for a median 7.5 years. The adjusted hazard ratio for disease-free survival for the 12 months versus the six months group was 1.08, 95 per cent confidence interval 0.93 to 1.25, P=0.39. The authors concluded non-inferiority of the six month course was not proven.
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