This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease BMA 2008; 337: 1030-1034

Published: 1st January 2008

Authors: Belch J, MacCuish A, Campbell I, Cobbe S, Taylor R, Prescott R et al et al.

Conclusion

This was a four-way study that included 1276 patients with diabetes. There was no evidence that aspirin, an antioxidant, or the combination affected the rate of cardiovascular events in this high risk population.

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