The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Treatment of acute venous thromboembolism with dabigatran or warfarin and pooled analysis. Circulation 2014; 129: 764-772.

Published: 14th April 2014

Authors: Schulman S, Kakkar AK, Goldhaber SZ, Schellong S, Eriksson H, Mismetti P et al. et al.

Conclusion

This study included 2589 patients with acute venous thromboembolism. The rate of recurrent DVT during six months of subsequent anticoagulation was 2.3 per cent with dabigatran and 2.2 per cent with warfarin.  Major bleeding rates were similar (1.2 versus 1.7 per cent respectively), but any bleeding complication was more common on warfarin: hazard ratio 0.67, 95 per cent confidence interval 0.56 to 0.81.

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