This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

A randomized phase II study of immunization with dendritic cells modified with poxvectors encoding CEA and MUC1 compared with same poxvectors plus GM-CSF for resected metastatic colorectal cancer. Ann Surg 2013; 285: 879–886.

Published: 18th February 2014

Authors: Morse MA, Niedzwiecki D, Marshall JL, Garrett C, Chang DZ, Aklilu M et al. et al.

Conclusion

In this study that included 74 patients who had complete resection of recurrent colorectal cancer treated with one of two immunisations, median recurrence-free survival at two years was 47 and 55 per cent in the two groups, an improvement compared with the survival rate of a contemporary groups of patients who were not vaccinated.

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