This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Amoxicillin plus clavulanic acid versus appendicetomy for treatment of acute uncomplicated appendicitis: an open-label, non inferiority, randomised controlled trial. Lancet 2011; 377: 1573–1579.

Published: 18th October 2011

Authors: Vons C, Barry C, Maitre S, Pautrat K, Leconte M, Costaglioli B et al. et al.

Conclusion

Some 243 patients with uncomplicated appendicitis diagnosed on CT were included. Of those randomized to antibiotic treatment, 14/120 had appendicectomy within 30 days and a further 30 within a year. Peritonitis within 30 days was (non-significantly) more common in the antibiotic group: 8 versus 2 per cent.

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