This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
IMPPACT (Intravenous Monotherapy for Postoperative Perforated Appendicitis in Children Trial). Randomized clinical trial of monotherapy versus multi-drug antibiotic therapy. Ann Surg 2021; 274: 406-410.
Published: 9th December 2021
Authors: Lee J, Garvey EM, Bundrant N, Hargis-Villanueva A, Kang P, Osuchukwu O et al.
Some 162 children were enrolled in the study. The rate of intra-abdominal abscess was significantly lower in children who had monotherapy: 6.1 versus 23.8 per cent, P=0.002.Pubmed Link
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A randomized clinical trial evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis. Results of the COMMA Trial. Ann Surg 2021; 274: 240-247.
Authors: O’Leary DP, Walsh SM, Bolger J, Baban C, Humphreys H, O’Grady S et al.
Effect of oral moxifloxacin vs intravenous ertapenem plus oral levofloxacin for treatment of uncomplicated acute appendicitis. The APPAC II randomized clinical trial. JAMA 2021; 325: 353-362.
Authors: Sipppola S, Haijanen J, Gronooos J, Rautio T, Nordstrom P, Rantanen T et al.
A randomized trial comparing antibiotics with appendectomy for appendicitis. N Engl J Med 2020; 383: 1907-1919.
Authors: The CODA Collaborative
Quality of life and patient satisfaction at 7-year follow-up of antibiotic therapy vs appendectomy for uncomplicated acute appendicitis. A secondary analysis of a randomized clinical trial. JAMA Surg 2020; 155: 283-289.
Authors: Sippola S, Haijanen J, Viinikainen L, Gronroos J, Paajanen H, Rautio T et al.
Are postoperative intravenous antibiotics indicated after laparoscopic appendicectomy for simple appendicitis? A prospective double-blinded randomized controlled trial. Ann Surg 2020; 272: 248-252.
Authors: Mennie N, Panabokke G, Chang A, Tanny ST, Cheng W, Pacilli M et al.
Non-operative treatment versus appendectomy for acute non-perforated appendicitis in children: five-year follow up of a randomized controlled pilot trial. Ann Surg 2020; 271: 1030-1035.
Authors: Patkova B, Svenningsson A, Almström M, Eaton S, Wester T, Svensson JF et al.
Povidone-iodine irrigation for pediatric perforated appendicitis may be protective. A Bayesian pilot randomized controlled trial. Ann Surg 2020; 271: 827-833
Authors: Anderson KT, Putnam LR, Bartz-Kurycki MA, Hamilton EC, Yafi M, Pedroza C et al.
Antibiotic treatment and appendectomy for uncomplicated acute appendicitis in adults and children. A systematic review and meta-analysis. Ann Surg 2019; 270: 1028-1040
Authors: Podda M, Gerardi C, Cillara N, Fearnhead N, Gomes CA, Birindelli A et al.
Risk of appendiceal neoplasm in periappendicular abscess in patients treated with interval appendectomy vs follow-up with magnetic resonance imaging. 1-year outcomes of the Peri–appendicitis Acuta randomized clinical trial. JAMA Surg 2019; 154: 200-207.
Authors: Mällinen J, Rautio T, Grönroos J, Rantanen T, Nordström P, Savolainen H et al.
A randomized double blinded study to determine the effectiveness of utilizing intraperitoneal bupivacaine: does it reduce postoperative opioid use following laparoscopic appendectomy? Am J Surg 2019; 217: 479-482.
Authors: Sevensma K, Schleichert T, Shwickerath C, Shoemaker A, Miller C
Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial. JAMA 2018; 320: 1259-1265.
Authors: Salminen P, Hannu Paajanen T, Rautio T, Nordström P, Aarnio M, Rantanen T et al.
Comparison of superficial surgical site infection between delayed primary versus primary wound closure in complicated appendicitis: a randomized controlled trial. Ann Surg 2018; 267: 631-637.
Authors: Siribumrungwong B, Chantip A, Noorit P, Wilasrusmee C, Ungpinitpong W, Chotiya P et al.