The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

IMPPACT (Intravenous Monotherapy for Postoperative Perforated Appendicitis in Children Trial). Randomized clinical trial of monotherapy versus multi-drug antibiotic therapy. Ann Surg 2021; 274: 406-410.

Published: 9th December 2021

Authors: Lee J, Garvey EM, Bundrant N, Hargis-Villanueva A, Kang P, Osuchukwu O et al.


Some 162 children were enrolled in the study. The rate of intra-abdominal abscess was significantly lower in children who had monotherapy: 6.1 versus 23.8 per cent, P=0.002.

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