This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis. The APPAC randomized clinical trial. JAMA. 2015; 313: 2340-2348.

Published: 27th October 2015

Authors: Salminen P, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T et al. et al.

Conclusion

The trial enrolled 530 patients with uncomplicated appendicitis diagnosed on CT. Some 70/257 (27 per cent) patients treated with antibiotics needed appendicectomy within a year. None had major complications after delayed surgery.

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