The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Association of intravenous tranexamic acid with thromboembolic events and mortality. A systematic review, meta-analysis, and meta-regression. JAMASurg 2021; 156: e210884.

Published: 24th November 2021

Authors: Taeuber I, Weibel S, Herrmann E, Neef V, Schlesinger TS, Kranke P et al.

Conclusion

This analysis that included 125,550 procedures showed no difference in perioperative thromboembolic events in tranexamic acid (2.1 per cent) or control groups (2.0 per cent). Tranexamic acid was associated with a reduction in overall deaths, and deaths from bleeding.

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