The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Prophylactic topical tranexamic acid versus placebo in surgical patients. A systematic review and meta-analysis. Ann Surg 2021; 273: 676-683.

Published: 1st July 2021

Authors: Teoh WY, Tan TG, Ng KT, Ong KX, Chan XL, Hung T et al.

Conclusion

Seventy-one trials including 7539 procedures were studied, mostly in orthopaedic surgery. Topical tranexamic acid reduced total blood loss (mean -319.55ml, P<0.001), reduced the need for blood transfusion (odds ratio 0.3, 95 per cent confidence interval 0.26 to 0.34), shortened hospital stay (mean -0.28 days, P=0.006), and did not increase adverse events.

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