This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia. BMJ 2016; 355: i6188.

Published: 2nd February 2017

Authors: Dulai PS, Singh S, Marquez E, Khera R, Prokop LJ, Limburg PJ et al.

Conclusion

The study included 14 RCTs. Non-steroidal anti-inflammatory drugs were best at reducing metachronous tumours (odds ratio 0.37, 95 per cent credible interval 0.24 to 0.53). Low dose aspirin was less effective (0.71, 0.41 to 1.23), but had a better safety profile.

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Effect of a deep-learning computer-aided detection system on adenoma detection during colonoscopy (CADE-DB trial): a double-blind randomised study. Lancet Gastroenterol Hepatol 2020; 5: 343-351.

Authors: Wang P, Liu X, Berzin TM, Glissen Brown JR, Liu P, Zhou C et al.

Scientific Surgery

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch Syndrome), a 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double blind, randomised, placebo-controlled trial. Lancet 2020; 395: 1855-1863.

Authors: Burn J, Sheth H, Elliott F, Reed L, Macrae F, Mecklin J-P et al.

Scientific Surgery

Modifiable pathways for colorectal cancer: a mendelian randomisation analysis. Lancet Gastroenterol Hepatol 2020; 5: 142-151

Authors: Cornish AJ, Law PJ, Tomofeeva M, Palin K, Farrington SM, Palles C et al.

Scientific Surgery

Efficacy and safety of sodium picosulfate/magnesium citrate for bowel preparation in a physically disabled outpatient population: a randomized, endoscopist-blinded comparison with ascorbic acid-enriched polyethylene glycol solution plus bisacodyl (The PICO-MOVI Study). Dis Colon Rectum 2018; 61: 239-249.

Authors: Mathus-Vliegen E, van der Vliet K, Wignand-van der Storm IJ, Stadwijk J

Scientific Surgery

Comparative evaluation of the efficacy of polyethylene glycol with ascorbic acid and an oral sulfate solution in a split method for bowel preparation: a randomized, multicenter phase III clinical trial. Dis Colon Rectum 2017; 60: 426-432.

Authors: Bun K, Lee SD, Han KS, Kim BC, Youk E-G, Nam MJ et al.

Scientific Surgery

Split-dose preparation for colonoscopy increases adenoma detection rate: a randomised controlled trial in an organised screening programme. Gut 2017; 66: 270-277.

Authors: Paggi S, Hassan C, Senore C, Fasoli R, Anderloni A, Buffoli F et al.

Scientific Surgery

Celecoxib for the prevention of colorectal adenomas: results of a suspended randomized controlled trial. J Natl Cancer Inst 2016; 108: djw151.

Authors: Thompson PA, Ashbeck EL, Roe DJ, Fales L, Buckmeier J, Wang F et al.

Scientific Surgery

Real-time optical diagnosis for diminutive colorectal polyps using narrow-band imaging: the VALID randomised clinical trial. Gut 2015; 64: 1569-1577.

Authors: Kaltenbach T, Rastogi A, Rouse RV, McQuaid KR, Sato T, Bansal A et al. et al.

Scientific Surgery

Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-analysis. Gut 2015; 64: 1419-1425.

Authors: Li P, Wu H, Zhang H, Shi Y, Xu J, Ye Y et al. et al.

Scientific Surgery

A trial of calcium and vitamin D for the prevention of colorectal adenomas. N Engl J Med 2015; 373: 1519-1530.

Authors: Baron JA, Barry EL, Mott LA, Rees JR, Sandler RS, Snover DC et al. et al.

Scientific Surgery

The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: a randomised trial. Gut 2014; 63: 1755-1759.

Authors: Ishikawa H, Mutoh M, Suzuki S, Tokudome S, Saida Y, Abe T et al. et al.

Scientific Surgery

Randomized clinical trial comparing reduced-volume oral picosulphate and a prepackaged low-residue diet with 4-liter PEG solution for bowel preparation. Dis Colon Rectum 2014; 57: 522-528.

Authors: Kim Ys, Hong CW, Kim BC, Han KS, Park JW, Seong Choi H et al. et al.