This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial. Lancet 2011; 377: 1749–1759.
Published: 5th August 2011
Authors: Seymour MT, Thompson LC, Wasan HS, Middleton G, Brewster AE, Shepherd SF et al.
Conclusion
A total of 459 patients with previously untreated advanced colorectal cancer were randomly allocated one of four chemotherapy regimens. Progression-free survival was not improved in any particular agent, but in general, combination treatment was better than single agent schedules, and capecitabine offered no advantage over fluorouracil.
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