This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 2006; 355: 1114-1123.
Published: 1st January 2006
Authors: Bosset J-F, Collette L, Calais G, Mineur L, Maingon P, Radosevic-Jelic L et al.
Conclusion
Four different combinations of delivery were investigated in 1011 patients. In those who received preoperative radiotherapy, adding fluorouracil pre or postoperatively did not affect survival. Chemotherapy given at any stage, however, significantly reduced the rate of local recurrence.
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