This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial. Lancet 2012; 380: 1909–1915.

Published: 16th April 2013

Authors: Laharie D, Bourreille A, Branche J, Allez M, Bouhnik Y, Filippi J et al. et al.

Conclusion

The outcomes were similar in the 115 patients with acute ulcerative colitis included in the study. Treatment failed in 60 per cent of patients that received ciclosporin and 54 per cent who had infliximab (P=0.52).

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