The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Clonidine in patients undergoing noncardiac surgery. N Engl J Med 2014; 370: 1504-1513.

Published: 5th February 2015

Authors: Devereaux P, Sessler DI, Leslie K, Kurz A, Mrkobrada M, Alonso-Coello P et al. et al.

Conclusion

This trial included 10,010 patients undergoing surgery in a 2x2 trial that included an aspirin arm. Clonidine did not reduce the rate of death or non fatal myocardial infarction, but did increase hypotension and non fatal cardiac arrest.

Pubmed Link