This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Hypothermic oxygenated machine perfusion reduces early allograft injury and improves post-transplant outcomes in extended criteria donation liver transplantation from donation after brain death. Ann Surg 2021; 274: 705-712.

Published: 9th December 2021

Authors: Czigany Z, Pratschke J, Froněk J, Guba M, Schöning W, Raptis DA et al.

Conclusion

Forty-six patients were included in this comparison of machine perfusion versus static cold storage. Machine perfusion reduced liver enzyme changes, 90-day complication rates, and ICU and hospital stay. There was a trend towards less early graft dysfunction: 17 versus 35 per cent, P=0.314.

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