This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial. BMJ 2011; 343: d3795.
Published: 18th October 2011
Authors: CRASH 2 Collaborators (Intracranial Bleeding Study).
Conclusion
One hundred and thirty-three patients were included. New focal brain lesions were seen in 5 per cent in the treatment and 9 per cent in controls (odds ratio 0.51, 95 per cent confidence interval 0.18 to 1.44), the death rate was 11 versus 18 per cent respectively (0.47, 0.21 to1.04).
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