This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Effect of tranexamic acid on surgical bleeding. Systematic review and cumulative meta-analysis. BMJ 2012; 344: e3054.

Published: 25th June 2012

Authors: Ker K, Edwards P, Perel P, Shakur H, Roberts I

Conclusion

There were 95 trials for review. Tranexamic acid reduced the need for transfusion by about one third: risk ratio 0.62, 95 per cent confidence interval 0.58 to 0.65, P<0.0001. Its effects on overall mortality remain uncertain, as do its effects on potential adverse effects such as myocardial infarction or stroke.

You may also be interested in

Scientific Surgery

Hypothermic oxygenated machine perfusion reduces early allograft injury and improves post-transplant outcomes in extended criteria donation liver transplantation from donation after brain death. Ann Surg 2021; 274: 705-712.

Authors: Czigany Z, Pratschke J, Froněk J, Guba M, Schöning W, Raptis DA et al.

Scientific Surgery

Open preperitoneal inguinal hernia repair, TREPP versus TIPP in a randomized clinical trial. Ann Surg 2021; 274: 698-704.

Authors: Bökkerink W, Koning G, Vriens PW, Mollen R, Harker M, Noordhof RK et al.

Scientific Surgery

Incisional surgical site infections after mass and layered closure of upper abdominal transverse incisions. First results of a randomized controlled trial. Ann Surg 2021; 274: 690-697.

Authors: Grąt M, Morawski M, Krasnodębski M, Borkowski J, Krawczyk P, Grąt K et al.

Scientific Surgery

Central venous access devices for the delivery of systemic anticancer therapy (CAVA): a randomised controlled trial. Lancet 2021; 398: 403-415.

Authors: Moss JG, Wo O, Bodenham AR, Agarwal R, Menne TF, Jones BL et al.

Scientific Surgery

Initial laparotomy versus peritoneal drainage in extremely low birthweight infants with surgical necrotizing enterocolitis or isolated intestinal perforation. A multicenter randomized clinical trial. Ann Surg 2021; 274: e370-e380.

Authors: Blakely M, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK et al.

Scientific Surgery

Randomized controlled study investigating the effect of a dedicated in-house art gallery on the recovery of patients after major oncologic surgery. Ann Surg 2021; 274: 264-270.

Authors: Lone Z, Hussein AA, Khan H, Steele M, Jing Z, Attwood K et al.

Scientific Surgery

Meta-analysis and systematic review of the use of a prosthetic mesh for prevention of parastomal hernia. Ann Surg 2021; 274: 20-28.

Authors: Prudhomme M, Fabbro-Peray P, Rullier E, Occean BV, Bertrand MM

Scientific Surgery

Oxygenated end-hypothermic machine perfusion in expanded criteria donor kidney transplant. A randomized clinical trial. JAMA Surg 2021; 156: 517-525.

Authors: Husen P, Boffa C, Jochmans I, Krikke C, Davies L, Mazilescu L et al.

Scientific Surgery

Association of intravenous tranexamic acid with thromboembolic events and mortality. A systematic review, meta-analysis, and meta-regression. JAMASurg 2021; 156: e210884.

Authors: Taeuber I, Weibel S, Herrmann E, Neef V, Schlesinger TS, Kranke P et al.

Scientific Surgery

Effect of a predictive model on planned surgical duration accuracy, patient wait time, and use of presurgical resources. A randomized clinical trial. JAMA Surg 2021; 156 :315-321.

Authors: Strömblad CT, Baxter-King R, Meisami A, Yee S-J, Levine MR, Ostrovsky A et al.

Scientific Surgery

Early corticosteroid cessation vs long-term corticosteroid therapy in kidney transplant recipients. Long-term outcomes of a randomized clinical trial. JAMA Surg 2021; 156: 307-314.

Authors: Woodle ES, Gill JS, Clark S, Stewart D, Alloway R, First R et al.

Scientific Surgery

Robotic versus laparoscopic ventral hernia repair. One-year results from a prospective, multicenter, blinded randomized controlled trial. Ann Surg 2021; 273: 1076-1080.

Authors: Dhanani N, Olavarria O, Holihan J, Shah S, Wilson T, Loor M et al.