This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Gastrointestinal tract recovery in patients undergoing bowel resection. Results of a randomised trial of alvimopan and placebo with a standardized accelerated postoperative care pathway Arch Surg. 2008; 143: 1098-1105

Published: 1st January 2008

Authors: Ludwig K, Enker WE, Delaney CP, Wolff BG, Du W, Fort JG et al et al.

Conclusion

A single oral dose of 12mg alvimopan given 30-90min before bowel resection speeded up gastrointestinal recovery (P<0.001) and reduced postoperative hospital stay: mean 5.2 vs. 6.2 days with placebo

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