This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Hydroxyethyl starch reduces coagulation competence and increases blood loss during major surgery: results from a randomized controlled trial. Ann Surg 2014; 259: 249-254.

Published: 11th September 2014

Authors: Rasmussen KC, Johansson PI, Hojskov M, Kridina I, Kistorp T, Thind P et al. et al.

Conclusion

In this study that included 38 patients, the use of hydroxyethyl starch increased the rate of blood loss compared with Ringer’s Lactate solution: 2.2 versus 1.4 Li (P<0.038). Patients in the starch group required more fluid overall (P<0.0001).

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