This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial. Arch Surg 2008; 143: 139-148.
Published: 1st January 2008
Authors: Bulger EM, Jurkovich GJ, Nathens AB, Copass MK, Hanson S, Cooper C et al.
Conclusion
A total of 209 patients were resuscitated either with Ringer’s lactate or hypertonic saline. The trial was stopped for futility after the second interim analysis; there was no difference in the rate of adult respiratory distress syndrome-free survival between the groups: hazard ratio 1.01, 95 per cent confidence interval 0.63 to 1.6.
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