This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in elderly inpatients (PLACIDE): a randomised double-blind, placebo-controlled multicentre trial. Lancet 2013; 382: 1249-1257.

Published: 18th March 2014

Authors: Allen SJ, Wareham K, Wang D, Bradley C, Hutchings H, Harris W et al. et al.

Conclusion

In this study that included nearly 3000 patients there was no evidence that the lactobacillus preparation reduced antibiotic-associated diarrhoea within eight weeks (10.8 per cent versus 10.4 per cent with placebo) or C. difficile (0.8 versus 1.2 per cent).

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