This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Multicenter randomized phase II clinical trial comparing neoadjuvant oxaliplatin, capecitabine and preoperative radiotherapy with and without cetuximab followed by total mesorectal excision in patients with high risk rectal cancer (EXPERT-C). J Clin Oncol 2012; 30: 1620-1627.
Published: 16th October 2012
Authors: Dewdney A, Cunningham D, Taberno J, Capdevila J, Glimelius B, Cervantes A et al. et al.
Conclusion
In this study that included 165 patients, the addition of cetuximab to the neoadjuvant regimen did not improve the rate of complete tumour response, but it did improve overall survival in patients with KRAS/BRAF wild type rectal cancer.
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