This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Neoadjuvant 5-FU or capecitabine plus radiation with or without oxaliplatin in rectal cancer patients: a phase III randomized clinical trial. J Natl Cancer Inst 2015; 107.
Published: 11th February 2016
Authors: Allegra C, Yothers G, O’Connell MJ, Beart RW, Wozniak TF, Pitot HC et al. et al.
Conclusion
Some 1608 patients were randomized to one of four different chemotherapy regimens in addition to preoperative radiotherapy. The oral capecitabine regimen was as effective as continuous 5-FU infusion; otherwise outcomes were all equivalent.
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