This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Out-of-hospital hypertonic resuscitation after traumatic hypovolemic shock: a randomised, placebo controlled trial. Ann Surg 2011; 253: 431–441.
Published: 7th June 2011
Authors: Bulger EM, May S, Kerby JD, Emerson S, Stiell IG, Schreiber MA et al.
Conclusion
Some 843 patients were initially treated out of hospital with one of three fluid regimens: normal saline, hypertonic saline or hypertonic saline with dextran. The trial was stopped early due to futility (23 per cent of proposed sample size); there was no difference between the groups in 28-day survival: 74.4, 73.0 and 74.5 per cent, respectively.
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