This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Perioperative total parenteral nutrition in malnourished, gastrointestinal cancer patients: a randomised clinical trial. J Ent Parent Nutr 2000; 24: 7-14.

Published: 1st January 2000

Authors: Bozetti F, Gavazzi C, Miceli R, Rossi N, Mariani L, Cozzaglio L. et al.

Conclusion

Ninety patients with gastric or colorectal tumours and weight loss of more than ten per cent were studied. TPN reduced the postoperative complication rate from 57 to 37 per cent (p=0.03), and the mortality rate from five to nil (p=0.05).

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IMPPACT (Intravenous Monotherapy for Postoperative Perforated Appendicitis in Children Trial). Randomized clinical trial of monotherapy versus multi-drug antibiotic therapy. Ann Surg 2021; 274: 406-410.

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A randomized clinical trial evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis. Results of the COMMA Trial. Ann Surg 2021; 274: 240-247.

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