This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomised phase III trial after a median follow-up of 11 years. J Clin Oncol 2012; 30: 1926–1933.
Published: 14th December 2012
Authors: Sauer R, Liersch T, Merkel S, Fietkau R, Hohenberger W, Hess C et al. et al.
Conclusion
Overall survival at ten years in this study that included 799 patients was 59.6 per cent after preoperative and 59.9 per cent after postoperative radiotherapy. The rates of distant metastases were similar, but the preoperative radiotherapy regimen improved the rate of local control: relapse rate 7.1 versus 10.1 per cent; P=0.048.
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