This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Randomized clinical trial of effect of synbiotics, neomycin and mechanical bowel preparation on intestinal barrier function in patients undergoing colectomy. Br J Surg 2007; 94: 546-554.

Published: 1st January 2007

Authors: Reddy BS, MacFie J, Gatt M, Larsen CN, Jensen SS, Leser TD. et al.

Conclusion

Patients randomized to a combination of neomycin, synbiotics and mechanical bowel preparation (n=20) had a lower incidence of bacterial translocation following colonic mobilisation (p<0.001) though there were no differences in inflammatory response or septic complications.

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