This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Randomized clinical trial of the effect of interferon alpha on survival in patients with disseminated midgut carcinoid tumours. Br J Surg 2003; 90: 687-93.

Published: 1st January 2003

Authors: Kölby L, Persson G, Franzén S, Ahrén B.

Conclusion

Sixty-eight patients with liver metastases were randomly allocated to interferon treatment in addition to their octreotide. Interferon reduced the rate of tumour progression but 5 year survival was not improved: 56.8 vs. 36.6 per cent, p=0.132.

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IMPPACT (Intravenous Monotherapy for Postoperative Perforated Appendicitis in Children Trial). Randomized clinical trial of monotherapy versus multi-drug antibiotic therapy. Ann Surg 2021; 274: 406-410.

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A randomized clinical trial evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis. Results of the COMMA Trial. Ann Surg 2021; 274: 240-247.

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