This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Randomized controlled pilot trial of nifedipine as oral therapy vs. topical application in the treatment of fissure-in-ano. Am J Surg 2013; 206: 748-751.

Published: 18th March 2014

Authors: Agrawal V, Kaushai G, Gupta R

Conclusion

Ninety patients were randomized to one of two active treatments or standard therapy. At three and eight weeks, topic nifedipine was associated with significantly better pain relief (P<0.05).

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Perioperative systemic therapy vs cytoreductive surgery and hyperthermic intraperitoneal chemotherapy alone for resectable colorectal peritoneal metastases. A phase 2 randomized clinical trial. JAMA Surg 2021; 156: 710-720.

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A randomized Phase II trial of adjuvant hepatic arterial infusion and systemic therapy with or without panitumumab after hepatic resection of KRAS wild-type colorectal cancer. Ann Surg 2021; 274: 248-254.

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Surgical management of idiopathic perianal fistulas: a systematic review and meta-analysis. Dig Surg 2021; 38: 104-119.

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Long-term outcomes of a randomized controlled trial of single-incision versus multi-port laparoscopic colectomy for colon cancer. Ann Surg 2021; 273: 1060-1065.

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Comparing laparoscopic elective sigmoid resection with conservative treatment in improving quality of life of patients with diverticulitis. The Laparoscopic Elective Sigmoid Resection Following Diverticulitis (LASER) randomized clinical trial. JAMA Surg 2021; 156: 129-136.

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Authors: Balvardi S, Pecorelli N, Castelino T, Niculiseanu P, Alhashemi M, Liberman AS et al.