This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials. BMJ 2012; 344: e2156.

Published: 15th August 2012

Authors: Varadhan KK, Neal KR, Lobo DN

Conclusion

Four randomized trials with a total of 900 patients were studied. Antibiotic treatment was associated with a reduced rate of complications: relative risk 0.69, 95 per cent confidence interval 0.54 to 0.89, P=0.004. Efficacy of treatment and duration of hospital stay were similar in the two groups.

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