This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
The TME trial after a median follow-up of six years: local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg 2007; 246: 693-701.
Published: 1st January 2007
Authors: Peeters KCMJ, Marijnen CAM, Nagtegaal ID, Kranenbarg EK, Putter H, Wiggers T et al.
Conclusion
The addition of preoperative radiotherapy reduced local recurrence from 10.9 to 5.6 per cent (P<0.001), but had no effect on overall survival (64.2 vs. 63.5 per cent, respectively), in this study that included 1861 procedures.
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